When there is one SARM that is always shrouded in mystery, then it needs to be GW501516 (Cardarine).
Although technically, it is not a SARM in any way.
There were controversies galore enclosing its use right since its origin.
First came reports of how it could change the way we treat obesity and lifestyle disorders associated with it.
Everyone was going gaga over it and suddenly, there came the studies that harshly and haphazardly labeled it a possible carcinogen.
This was followed by additional research that showed it as a potential cancer treatment.
Which is it truly?
Does it amplify the rate at which cancer cells proliferate into forming tumors?
Was a highly exaggerated study conducted at extreme doses for unrealistically long time frames?
We know that you probably did not anticipate this guide to start this way. But we can’t address the advantages of Cardarine unless we tackle the controversies.
AN OVERVIEW OF GW501516
Cardarine or GW501516 is an investigational research medication that was developed from the early 90s by Ligand and GSK as a possible therapeutic aid for metabolic and cardiovascular diseases.
This really is a PPARδ (Peroxisome Proliferator-Activator Receptor-delta) agonist which works by activating the PPAR-delta pathway at specific receptor sites in the entire body.
In UG labs, it is frequently marketed under the moniker’Enduborol’ owing to the characteristic to boost endurance.
In the peak of its popularity, Cardarine was regarded as THE answer that science has been searching for ailments like hyperlipidemia, obesity and diabetes.
In reality, despite GSK and Ligand quitting the manufacturing and studies, independent investigators continue to study Cardaine and PPARb/d ligands because of its program and security.
Like most research chemicals in these times, Cardarine made its way to the bodybuilding and athletic community in the late 1990s.
It is widely believed (not supported ) that at the 2008 Olympics in Beijing, a large number of athletes were utilizing Cardarine.
What results can you get with Cardarine?
There is a reason GW501516 is called Enduborol. That is because the first and most remarkable impact is the rise in endurance.
That is what makes it desirable for athletes out of a functionality enhancement point of view.
But that’s not all.
Among the ramifications of activating the PPAR-delta pathway is lipolysis. GW501516 signals the body to utilize stored fat rather than muscle. This really has a two-pronged impact. Firstly, your metabolism is revved up and you begin to burn more organ-clogging fat. Secondly, this gives you a consistent source of energy. Not a skewed graph as is the case with stimulant-laden fat burners.
We reveal that the oral PPARδ agonist GW501516 is capable of considerably improving impaired oxidative metabolism in skeletal muscle.
Am J Physiol Heart Circ Physiol. 2015 May 1; 308(9): H1078–H1085.
Cardarine kicks in within days of the cycle and the results are almost magical. You can bang out more reps in the gym without getting pooped, your cardiovascular capacity skyrockets. Many athletes report having the ability to breathe easier. Some say that their lungs felt lighter if they had been on the chemical. That’s the reason multiple athletes are caught on Cardarine. Long-distance cyclists, runners, sprinters, anyone in competitive sports may gain a benefit with Cardarine. Bodybuilders on a Trenbolone cycle incorporate it to their pile for exactly the exact same reason.
While it makes it possible to burn fat; it also can help you keep muscle. That’s comparable to what anabolic steroids do. Consider the possible applications of this medication in a hardcore cutting cycle or through competition prep.
A lot of athletes start using Cardarine purely for its therapeutic benefits. One of that is faster recover from injury and reduced inflammation in muscular tissue. Cardarine also helps to reduce inflammation in brain cells and might protect from the damage caused due to oxidative stress.
Using steroids that are unpleasant on your lipid levels? Cardarine can help lower LDL levels while raising the amount of HDL. Think of it like adding a cholesterol medication which also offers tons of different advantages.
Another reason to consider adding it to your own steroid stack, especially if you’re using orals. Cardarine helps reduce inflammation in the liver, prevents insulin resistance and might protect the liver from steroid-induced harm.
CAN CARDARINE INDUCE CANCER? WHAT ARE THE DIFFERENT SIDE EFFECTS?
To be honest, there is a whole lot of contradictory information on the market at the present time about Cardarine and cancer.
What we do know is that the only clinical research that connected it with a potential increase in cancer cells has been conducted for nearly 2 decades in Han Wistar rats that have a lifespan of roughly 3-years.
They have been administered Cardarine at five to six times the standard dose for such an extended period duration.
Yes, the mice developed cancer and tumors at almost every organ in their body.
The question to be asked is, will you use Cardarine at five times the recommended dose for two years at one time?
If yes, then it may cause cancer or it might not. We simply don’t know.
What we do know is that at low doses, the results achievable with the chemical are nothing short of remarkable.
And it does not lead to any serious side effects at the dose.
Moreover, you will find more recent studies that reveal how Cardarine might, in fact, stop cancer cells from proliferating.
This study provides additional evidence that GW501516-activated PPARβ/δ reduces TNFα-induced Nfkb1 action and inflammatory signaling via direct induction of anti-inflammatory genes, along with indirect inhibition of pro-inflammatory genes by BCL6 dissociation in human pancreatic cancer cells.
Biochem Biophys Rep. 2016 Dec; 8: 395–402.
Until there’s some clarity with this, we’d say you take the carcinogen claim with a large grain of salt.
WHAT’S A SAFE/RECOMMENDED DOSE FOR CARDARINE?
It’s strongly suggested that you begin with 10mg per day for a few weeks and then, raise it to 20mg/day.
Some athletes take around 30mg/day with zero sides.
But it will be in your very best interest to stick to this 20mg dose.
The cycle length can be up to 8-weeks.
Most experienced SARM users have now started to use it for shorter cycles however.
So, even just a 5-week cycle might provide you great results.
GW501516 is among the most effective substances to have been ever introduced to the world of performance-enhancing drugs.
There are only good things to write about it and it is generally, well-tolerated.
Having said that, you should use such a highly effective compound sensibly.
Don’t go overboard with all the dose or cycle period and always purchase from a reputed source.